本研究室での研究論文一覧です（アンダーラインは本研究室メンバーです：研究実施時のメンバーを含みます）。
Maki J, Hanaki Y, Yanagita RC, Kikumori M, Kovba A, Washizaki A, Tsukano C, Akari H, Irie K: Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, Biotechnology, and Biochemistry 87(12), 1453-1461, 2023.
Murayama A, Akari H, Kato T: Production and
purification of cell culture-generated hepatitis B virus by transient transfection and density gradient. Bio-protocol 13, e4779, 2023.
Murata M, Kovba A, Kaneko A, Morimoto M, Ishigami A, Natsume T, Washizaki A, Miyabe-Nishiwaki T, Suzuki J, Akari H: Annual two-dose tetanus toxoid vaccination induces protective humoral immunity to all age groups of rhesus macaques. Experimental Animals, 72(4), 490-495, 2023.
Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses. PLoS Pathogens 19, e1011104, 2023.
Ode H, Saito A, Washizaki A, Seki Y, Yoshida T, Harada S, Ishii H, Shioda T, Yasutomi Y, Matano T, Miura T, Akari H*, Iwatani Y*: Development of a novel macaque-tropic HIV-1 adapted to cynomolgus macaques. Journal of General Virology 103, 0001790, 2022.
(*; co-corresponding authors)
Washizaki A, Murayama A, Murata M, Kiyohara T, Yato K, Yamada N, Aly HH, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Goh Y, Ishii KJ, Yotsuyanagi H, Muramatsu M, Ishii K, Takahashi Y, Suzuki R, Akari H*, Kato T*: Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs. Nature Communications 13, 5207, 2022. (*: co-corresponding authors)
Sato H, Murakami T, Matsuura R, Abe M, Matsuoka S, Yashiroda Y, Yoshida M, Akari H, Nagasawa Y, Takei M, Aida Y: A novel class of HIV-1 inhibitors targeting the Vpr-induced G2-arrest in macrophages by new yeast- and cell-based high-throughput screening. Viruses 14, 1321, 2022.
Seki Y, Kitamura T, Tezuka K, Murata M, Akari H, Hamaguchi I, Okuma K: Cytolytic recombinant vesicular stomatitis viruses expressing STLV-1 receptor specifically eliminate STLV-1 Env-expressing cells in an HTLV-1 surrogate model in vitro. Viruses 14, 740, 2022.
Washizaki A, Murata M, Seki Y, Kikumori M, Tang Y, Tan W, Wardani NP, Irie K, Akari H: Synergistic HIV reactivation and minimal global activation by the novel PKC activator 10-Methyl-aplog-1 in combination with JQ1. Viruses 13, 2037, 2021.
, 2021.
Iwamoto Y, Seki Y, Taya K, Tanaka M, Iriguchi S, Miyake Y, Nakayama EE, Miura T, Shioda T, Akari H, Takaori-Kondo A, Kaneko S: Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease. Molecular Therapy: Methods & Clinical Development 21, 262-273, 2021.
Matsuoka S, Kuwata T, Ishii H, Sekizuka T, Kuroda M, Sano M, Takeda A, Okazaki M, Yamamoto H, Shimizu M, Matsushita S, Seki Y, Saito A, Sakawaki H, Hirsch MV, Miura T, Akari H, Matano T: A potent anti-simian immunodeficiency virus neutralizing antibody induction associated with a germline immunoglobulin gene polymorphism in rhesus macaques.
Journal of Virology 95, e02455-20, 2021.
Izaki M, Yasunaga J-i, Nosaka K, Sugata K, Utsunomiya H, Suehiro Y, Shichijo T, Yamada A, Sugawara Y, Hibi T, Inomata Y, Akari H, Melamed A, Bangham C, Matsuoka M: In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions.
PLoS Pathogens 17, e1009271, 2021.
Murata M, Yasunaga J-i, Washizaki A, Seki Y, Kuramitsu M, Tan W, Hu A, Okuma K, Hamaguchi I, Mizukami T, Matsuoka M, Akari H: Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques. Retrovirology 17, 15, 2020.
Miyabe-Nishiwaki T, Maclntosh AJJ, Kaneko A, Morimoto M, Suzuki J, Akari H, Okamoto M: Hematological and blood chemistry values in captive Japanese macaques (Macaca fuscata fuscata). Journal of Medical Primatology 48, 338-350, 2019.
Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A: PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.
Nature Communications 10, 1844, 2019.
Seki Y, Akari H: Approaches for the Achievement of HIV cure using the non-human primate models. Journal of AIDS Research 21, 147-158, 2019.
Naruse TK, Akari H, Matano T, Kimura A: Diversity of ULBP5 in Old World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates. Proceedings of the Japan Academy, Series B 94, 441-453, 2018.
Yokokawa H, Higashino A, Suzuki S, Moriyama
M, Nakamura N, Suzuki T, Suzuki R, Ishii K, Kobiyama K, Ishii K, Wakita T, Akari H*, Kato T*. Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a
non-human primate model. Gut 67, 372-379, 2018. (*: co-corresponding authors)
Nakashima M, Tsuzuki S, Awazu H, Hamano A, Okada A, Ode H, Maejima M, Hachiya A, Yokomaku Y, Watanabe N, Akari H, Iwatani Y: Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif. Journal of Molecular Biology 429, 1262-1276, 2017.
Furuta R, Yasunaga J, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa J, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M: Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathogens 13, e1006722, 2017.
Suzuki S, Mori KI, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, Akari H: Persistent replication of hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. Microbiology and Immunology 30, 26-34, 2016.
Sultana T, Nakayama EE, Tobita S, Yokoyama M, Seki Y, Saito A, Nomaguchi M, Adachi A, Akari H, Sato H, Shioda T: Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis. Journal of General Virology 97, 963-976, 2016.
Sugata K, Yasunaga J-i, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M: Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.
Scientific Reports 6, 27150, 2016.
Yoshida T, Takemoto H, Sakamaki T, Tokuyama N, Hart J, Hart T, Dupain J, Cobden A, Mulavwa M, Kawamoto Y, Kaneko A, Enomoto Y, Sato E, Kooriyama T, Miyabe-Nishiwaki T, Suzuki J, Saito A, Okamoto M, Tomonaga M, Matsuzawa T, Furuichi T, Akari H: Epidemiological surveillance of lymphocryptovirus infection in wild bonobos. Frontiers in Microbiology 10, 3389, 2016.
Sultana T, Nakayama EE, Tobita S, Yokoyama M, Seki Y, Saito A, Nomaguchi M, Adachi A, Akari H, Sato H, Shioda T. Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgusmacaque TRIMCyp generated by random mutagenesis. Journal of General Virology 9, 963-976, 2016.
Suzuki S, Mori KI, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, Akari H. Microbiol Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. Microbiology and Immunology 30, 26-34, 2016.
Nomura T, Yamamoto H, Ishii H, Akari H, Naruse TK, Kimura A, Matano T. Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers. PLoS Pathogens 11, e1005247, 2015.
Yoshida T, Akari H: Role of accessory proteins in primate immunopathogenesis. Journal of AIDS Research 17, 7-13, 2015.
Ma G, Yasunaga J, Akari H, Matsuoka M. TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. Proceedings of the National Academy of Science USA 112, 2216-2221, 2015.
Okamoto M, Miyazawa T, Morikawa S, Ono F, Nakamura S, Sato E, Yoshida T, Yoshikawa R, Sakai
K, Mizutani T, Nagata N, Takano J, Okabayashi S, Hamano M, Fujimoto K, Nakaya T, Iida T, Horii T, Miyabe-Nishiwaki T, Watanabe A, Kaneko A, Saito A, Matsui A, Hayakawa T, Suzuki J,
Akari H, Matsuzawa T, Hirai H. Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.
Scientific Reports 5, 8850, 2015.
Saito A, Kono K, Kawamoto Y, Higashino A, Suzuki S, Yoshida T, Torii R, Yasutomi Y, Shioda T, Nakayama EE, Akari H: Diversity of antiretroviral host factor trim5 gene in macaque monkeys: genetic information for establishment of HIV-1 primate model. Journal of AIDS Research 2014, 16, 28-36.
Fujie Y, Fusaki N, Katayama T, Hamasaki M, Soejima Y, Soga M, Ban H, Hasegawa M, Yamashita S, Kimura
S, Suzuki S, Matsuzawa T, Akari H, Era T: New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood. PLoS One 5,
e113052, 2014.
Shimoda H, Saito A, Noguchi K, Terada Y, Kuwata R, Akari H, Takasaki T, Maeda K: Seroprevalence of Japanese encephalitis virus infection in captive Japanese macaques (Macaca fuscata). Primates 55, 441-445, 2014.
Naruse TK, Akari H, Matano T, Kimura A: Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques. Immunogenetics 66, 161-170, 2014.
Moi ML, Takasaki T, Omatsu T, Nakamura S, Katakai Y, Ami Y, Yuriko S, Saijo M, Akari H, Kurane I: Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viremia and serotype cross-reactive antibody responses consistent with secondary infection of humans. Journal of General Virology 95, 591-600, 2014.
Miura M, Yasunaga J, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H, Matsuoka M: Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology 10, 118, 2013.
Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, FujiwaraS, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A: Generation of rhesus macaque-tropic HIV-1clones that are resistant to major anti-HIV-1 restriction factors. Journal of Virology 87, 11447-11461, 2013.
Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H: Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration. Immunology Letters 154, 12-17, 2013.
Saito A, Akari H: Macaque-tropic human immunodeficiency virus type 1 (HIV-1mt): Break out of the host factors. Frontiers in Microbiology 4, 187, 2013.
Moi ML, Omatsu T, Hirayama T, Nakamura S, Katakai Y, Yoshida T, Saito A, Tajima S, Ito M, Takasaki T, Akari H, Kurane I: Presence of viral genome in urine and development of hematuria and pathological changes in kidneys in common marmoset (Callithrix jacchus) after inoculation with dengue virus. Pathogens 2, 357-363, 2013.
Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama EE, Akari H: TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1. Journal of General Virology 94, 1318-1324, 2013.
Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H: Dynamics of cellular immune responses in the acute phase of dengue virus infection. Archives of Virology 158, 1209-1220, 2013.
Nomaguchi M, Doi N, Fujiwara S, Saito A, Akari H, Nakayama EE, Shioda T, Yokoyama M, Sato H, Adachi A: Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells. Microbes and Infection 15, 319-328, 2013.
Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi A: Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells. Microbes and Infection 15, 56-65, 2013.
Kooriyama T, Okamoto M, Yoshida T, Nishida T, Tsubota T, Saito A, Tomonaga M, Matsuzawa T, Akari H, Nishimura H, Miyabe-Nishiwaki T: Epidemiological study of zoonoses derived from humans in captive chimpanzees. Primates 54, 89-98, 2013.
Saito A, Kawamoto Y, Higashino A, Yoshida T, Ikoma T, Suzaki Y, Ami Y, Shioda T, Nakayama EE, Akari H: Allele Frequency of Antiretroviral Host Factor TRIMCyp in Wild-caught Cynomolgus Macaques (Macaca fascicularis). Frontiers in Microbiology 3, 314, 2012.
Omatsu T, Moi ML, Takasaki T, Nakamura S, Katakai Y, Tajima S, Ito M, Yoshida T, Saito A, Akari H, Kurane I: Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus. Journal of Medical Primatology 41, 289-296, 2012.
Ohtani H, Naruse TK, Iwasaki Y, Akari H, Ishida T, Matano T, Kimura A: Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates. Immunogenetics 64, 669-678, 2012.
Iijima S, Lee Y-J, Ode H, Arold ST, Kimura N, Yokoyama M, Sato H, Tanaka Y, Strebel K, Akari H: A non-canonical mu-1A-binding motif in the N-terminus of HIV-1 Nef determines its activity to down-regulate MHC-I in T lymphocytes. Journal of Virology 86, 3944-51, 2012.
Saito A, Kono K, Nomaguchi M, Yasutomi Y, Adachi A, Shioda T, Akari H, Nakayama EE: Geographic, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis). Journal of General Virology 93, 594-602, 2012.
Takeuchi H, Ishii H, Kuwano T, Inagaki N, Akari H, Matano T:
Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication. Retrovirology 9, 3, 2012.
Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H: CD16 positive natural killer cells play a limited role against primary dengue virus infection in tamarins. Archives of Virology 157, 363-368, 2012.
Saito Y, Naruse TK, Akari H, Matano T, Kimura A: Diversity of MHC class I haplotypes in cynomolgus macaques. Immunogenetics 64, 131-141, 2012.
Iwasaki Y, Mori K, Ishii K, Maki N, Iijima S, Yoshida T, Okabayashi S, Katakai Y, Lee Y-J, Saito A, Fukai H, Kimura N, Ageyama N, Yoshizaki S, Suzuki T, Yasutomi Y, 9, 9, Miyamura T, Kannagi M, Akari H: Long-term persistent GBV-B infection and development of a progressive chronic hepatitis C–like disease in marmosets. Frontiers in Microbiology 2, 240, 2011.
Omatsu T, Moi ML, Hirayama T, Takasaki T, Nakamura S, Tajima S, Ito M, Yoshida T, Saito A, Katakai Y, Akari H, Kurane I: Common marmoset (Callithrix jacchus) as a primate Model of dengue virus infection: development of high levels of viremia and demonstration of protective immunity. Journal of General Virology 92, 2272-2280, 2011.
Naruse TK, Okuda Y, Mori K, Akari H, Matano T, Kimura A: ULBP4/RAET1E is highly polymorphic in the Old World monkey. Immunogenetics 63, 501-509, 2011.
Ito M, Katakai Y, Ono F, Akari H, Mukai RZ, Takasaki T, Kotaki A, Kurane I: Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes. Archives of Virology 156, 1073-1077, 2011.
Ohtani H, Nakajima T, Akari H, Ishida T, Kimura A: Molecular evolution of immunoglobulin superfamily genes in primates. Immunogenetics 63, 417-428, 2011.
Saito A, Nomaguchi M, Iijima S, Kuroishi A, Yoshida T, Lee YJ, Hayakawa T, Kono K, Nakayama EE, Shioda T, Yasutomi Y, Adachi A, Matano T, Akari H: Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. Microbes and Infection 13, 58-64, 2011.
Yoshida T, Saito A, Iwasaki Y, Iijima S, Kurosawa T, Katakai Y, Yasutomi Y, Reimann KA, Hayakawa T, Akari H: Characterization of natural killer cells in tamarins: a technical basis for studies of innate immunity. Frontiers in Microbiology 1, 128, 2010.
Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A: Diversity of MHC class I genes in Burmese-origin rhesus macaques. Immunogenetics 62, 601-611, 2010.
Matsumoto Y, Miura T, Akari H, Goto Y, Haga T: Peripheral blood CD4 CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5. Journal of Veterinary Medical Science 72, 1057-1061, 2010.